High rate of in-stent restenosis after coronary intervention in carriers of the mutant mannose-binding lectin allele
In-stent restenosis occurs in 10-30% of patients following bare metal stent (BMS) implantation and has various risk factors. Mannose-binding lectin (MBL) is known to have effect on the progression of atherosclerosis. Single nucleotide polymorphisms (SNP) of the MBL2 gene intron 1 (codon 52, 54, 57)...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 January 2017
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| In: |
BMC cardiovascular disorders
Year: 2017, Volume: 17 |
| ISSN: | 1471-2261 |
| DOI: | 10.1186/s12872-016-0440-y |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s12872-016-0440-y Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12872-016-0440-y 
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| Author Notes: | Zsolt Bagyura, Loretta Kiss, Balázs Berta, Ágnes Szilágyi, Kristóf Hirschberg, Gábor Széplaki, Árpád Lux, Zsolt Szelid, Pál Soós, Béla Merkely |
| Summary: | In-stent restenosis occurs in 10-30% of patients following bare metal stent (BMS) implantation and has various risk factors. Mannose-binding lectin (MBL) is known to have effect on the progression of atherosclerosis. Single nucleotide polymorphisms (SNP) of the MBL2 gene intron 1 (codon 52, 54, 57) are known to modulate the bioavailability of the MBL protein. Our aim was to identify the association of these polymorphisms of the MBL gene in the occurrence of in-stent restenosis after coronary artery bare metal stent implantation. |
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| Item Description: | Published: 5 January 2017 Gesehen am 15.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1471-2261 |
| DOI: | 10.1186/s12872-016-0440-y |