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High rate of in-stent restenosis after coronary intervention in carriers of the mutant mannose-binding lectin allele

In-stent restenosis occurs in 10-30% of patients following bare metal stent (BMS) implantation and has various risk factors. Mannose-binding lectin (MBL) is known to have effect on the progression of atherosclerosis. Single nucleotide polymorphisms (SNP) of the MBL2 gene intron 1 (codon 52, 54, 57)...

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Bibliographische Detailangaben
Hauptverfasser: Bagyura, Zsolt (VerfasserIn) , Hirschberg, Kristóf (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 5 January 2017
In: BMC cardiovascular disorders
Year: 2017, Jahrgang: 17
ISSN:1471-2261
DOI:10.1186/s12872-016-0440-y
Online-Zugang:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s12872-016-0440-y
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12872-016-0440-y
Volltext
Verfasserangaben:Zsolt Bagyura, Loretta Kiss, Balázs Berta, Ágnes Szilágyi, Kristóf Hirschberg, Gábor Széplaki, Árpád Lux, Zsolt Szelid, Pál Soós, Béla Merkely
Beschreibung
Zusammenfassung:In-stent restenosis occurs in 10-30% of patients following bare metal stent (BMS) implantation and has various risk factors. Mannose-binding lectin (MBL) is known to have effect on the progression of atherosclerosis. Single nucleotide polymorphisms (SNP) of the MBL2 gene intron 1 (codon 52, 54, 57) are known to modulate the bioavailability of the MBL protein. Our aim was to identify the association of these polymorphisms of the MBL gene in the occurrence of in-stent restenosis after coronary artery bare metal stent implantation.
Beschreibung:Published: 5 January 2017
Gesehen am 15.08.2018
Beschreibung:Online Resource
ISSN:1471-2261
DOI:10.1186/s12872-016-0440-y

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