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Applying microdroplets as sensors for label-free detection of chemical reactions

Despite its tremendous high-throughput screening capabilities, widespread applications of droplet-based microfluidics are still limited by the poor availability of appropriate analytical assays. Here we report on a novel sensor method that exploits the osmosis-driven change in droplet size as a quan...

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Bibliographic Details
Main Authors: Hofmann, Tobias (Author) , Hänselmann, Siegfried (Author) , Janiesch, Jan-Willi (Author) , Rademacher, Anne (Author) , Böhm, Christian H. J. (Author)
Format: Article (Journal)
Language:English
Published: 17 Jan 2012
In: Lab on a chip
Year: 2012, Volume: 12, Issue: 5, Pages: 916-922
ISSN:1473-0189
DOI:10.1039/C2LC20971C
Online Access:Verlag, Volltext: http://dx.doi.org/10.1039/C2LC20971C
Verlag, Volltext: https://pubs.rsc.org/en/content/articlelanding/2012/lc/c2lc20971c
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Author Notes:Tobias W. Hofmann, Siegfried Hänselmann, Jan-Wilhelm Janiesch, Anne Rademacher, Christian H.J. Böhm
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Summary:Despite its tremendous high-throughput screening capabilities, widespread applications of droplet-based microfluidics are still limited by the poor availability of appropriate analytical assays. Here we report on a novel sensor method that exploits the osmosis-driven change in droplet size as a quantitative and label-free marker for reactions inside the droplets. We present an analysis of the underlying mechanism and apply the method for monitoring metabolic activity at a single-cell level.
Item Description:Gesehen am 16.08.2018
Physical Description:Online Resource
ISSN:1473-0189
DOI:10.1039/C2LC20971C

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