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Applying microdroplets as sensors for label-free detection of chemical reactions

Despite its tremendous high-throughput screening capabilities, widespread applications of droplet-based microfluidics are still limited by the poor availability of appropriate analytical assays. Here we report on a novel sensor method that exploits the osmosis-driven change in droplet size as a quan...

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Bibliographische Detailangaben
Hauptverfasser: Hofmann, Tobias (VerfasserIn) , Hänselmann, Siegfried (VerfasserIn) , Janiesch, Jan-Willi (VerfasserIn) , Rademacher, Anne (VerfasserIn) , Böhm, Christian H. J. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 17 Jan 2012
In: Lab on a chip
Year: 2012, Jahrgang: 12, Heft: 5, Pages: 916-922
ISSN:1473-0189
DOI:10.1039/C2LC20971C
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1039/C2LC20971C
Verlag, Volltext: https://pubs.rsc.org/en/content/articlelanding/2012/lc/c2lc20971c
Volltext
Verfasserangaben:Tobias W. Hofmann, Siegfried Hänselmann, Jan-Wilhelm Janiesch, Anne Rademacher, Christian H.J. Böhm
Beschreibung
Zusammenfassung:Despite its tremendous high-throughput screening capabilities, widespread applications of droplet-based microfluidics are still limited by the poor availability of appropriate analytical assays. Here we report on a novel sensor method that exploits the osmosis-driven change in droplet size as a quantitative and label-free marker for reactions inside the droplets. We present an analysis of the underlying mechanism and apply the method for monitoring metabolic activity at a single-cell level.
Beschreibung:Gesehen am 16.08.2018
Beschreibung:Online Resource
ISSN:1473-0189
DOI:10.1039/C2LC20971C

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