Re-irradiation in recurrent malignant glioma: prognostic value of [18F]FET-PET
The aim of the present study is to determine new positron emission tomography (PET) imaging-related factors predictive of progression-free survival as well as survival in patients with recurrent malignant glioma (MG) prior to and after re-irradiation. Fifty-six patients with recurrent MG who underwe...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
04 October 2012
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| In: |
Journal of neuro-oncology
Year: 2012, Volume: 110, Issue: 3, Pages: 389-395 |
| ISSN: | 1573-7373 |
| DOI: | 10.1007/s11060-012-0980-7 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/s11060-012-0980-7 Verlag, Volltext: https://link.springer.com/article/10.1007/s11060-012-0980-7 
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| Author Notes: | Maximilian Niyazi, Nathalie Jansen, Ute Ganswindt, Silke Birgit Schwarz, Julia Geisler, Oliver Schnell, Karen Büsing, Sabina Eigenbrod, Christian la Fougère, Claus Belka |
| Summary: | The aim of the present study is to determine new positron emission tomography (PET) imaging-related factors predictive of progression-free survival as well as survival in patients with recurrent malignant glioma (MG) prior to and after re-irradiation. Fifty-six patients with recurrent MG who underwent re-irradiation treatment and pretherapeutic dynamic [18F]-fluoroethyl-l-tyrosine (FET)-PET scan were retrospectively analyzed. The prognostic value of different parameters, such as biological tumor volume, maximal tumor uptake (SUVmax/BG), mean tumor uptake (SUVmean/BG), as well as uptake kinetics, was evaluated. [18F]FET uptake kinetics was classified according to a five-point rating as category G1-2 (strongly/mainly increasing kinetics), G3 (mixed 1:1), or G4-5 (mainly/strongly decreasing kinetics). Patients within the pretherapeutic kinetic group G4-5 had significantly worse survival than the other two groups (p = 0.01). Multivariate analysis revealed that histologic grade, Karnofsky Performance Score (KPS), and kinetic group were independent significant predictors for survival after re-irradiation. The uptake kinetics of [18F]FET-PET is an independent determinant of overall and to a lesser extent also progression-free survival. Thus, [18F]FET-PET kinetics may provide valuable additional prognostic information for treatment decisions. |
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| Item Description: | Gesehen am 16.08.2018 Im Titel ist "18" in [18F]FET-PET hochgestellt |
| Physical Description: | Online Resource |
| ISSN: | 1573-7373 |
| DOI: | 10.1007/s11060-012-0980-7 |