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Joint features and complementarities of Tspan8 and CD151 revealed in knockdown and knockout models

Tetraspanins are highly conserved 4-transmembrane proteins which form molecular clusters with a large variety of transmembrane and cytosolic proteins. By these associations tetraspanins are engaged in a multitude of biological processes. Furthermore, tetraspanin complexes are located in specialized...

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Bibliographic Details
Main Authors: Yue, Shijing (Author) , Zhao, Kun (Author) , Erb, Ulrike (Author) , Rana, Sanyukta (Author) , Zöller, Margot (Author)
Format: Article (Journal)
Language:English
Published: 13 April 2017
In: Biochemical Society transactions
Year: 2017, Volume: 45, Issue: 2, Pages: 437-447
ISSN:1470-8752
DOI:10.1042/BST20160298
Online Access:Verlag, Volltext: http://dx.doi.org/10.1042/BST20160298
Verlag, Volltext: http://www.biochemsoctrans.org/content/45/2/437
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Author Notes:Shijing Yue, Kun Zhao, Ulrike Erb, Sanyukta Rana and Margot Zöller
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Summary:Tetraspanins are highly conserved 4-transmembrane proteins which form molecular clusters with a large variety of transmembrane and cytosolic proteins. By these associations tetraspanins are engaged in a multitude of biological processes. Furthermore, tetraspanin complexes are located in specialized microdomains, called tetraspanin-enriched microdomains (TEMs). TEMs provide a signaling platform and are poised for invagination and vesicle formation. These vesicles can be released as exosomes (Exo) and are important in cell contact-independent intercellular communication. Here, we summarize emphasizing knockdown and knockout models' pathophysiological joint and selective activities of CD151 and Tspan8, and discuss the TEM-related engagement of CD151 and Tspan8 in Exo activities.
Item Description:Gesehen am 21.08.2018
Physical Description:Online Resource
ISSN:1470-8752
DOI:10.1042/BST20160298

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