The hallmarks of cancer
With the advent of next generation sequencing methods and progress in transcriptome analysis, it became obvious that the human genome contains much more than just protein-coding genes. In fact, up to 70% of our genome is transcribed into RNA that does not serve as templates for proteins. In this rev...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 Jun 2012
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| In: |
RNA biology
Year: 2012, Volume: 9, Issue: 6, Pages: 703-719 |
| ISSN: | 1555-8584 |
| DOI: | 10.4161/rna.20481 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.4161/rna.20481 Verlag, kostenfrei, Volltext: https://doi.org/10.4161/rna.20481 Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pubmed/22664915 
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| Author Notes: | Tony Gutschner, Sven Diederichs |
| Summary: | With the advent of next generation sequencing methods and progress in transcriptome analysis, it became obvious that the human genome contains much more than just protein-coding genes. In fact, up to 70% of our genome is transcribed into RNA that does not serve as templates for proteins. In this review, we focus on the emerging roles of these long non-coding RNAs (lncRNAs) in the field of tumor biology. Long ncRNAs were found to be deregulated in several human cancers and show tissue-specific expression. Functional studies revealed a broad spectrum of mechanisms applied by lncRNAs such as HOTAIR, MALAT1, ANRIL or lincRNA-p21 to fulfill their functions. Here, we link the cellular processes influenced by long ncRNAs to the hallmarks of cancer and therefore provide an ncRNA point-of-view on tumor biology. This should stimulate new research directions and therapeutic options considering long ncRNAs as novel prognostic markers and therapeutic targets. |
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| Item Description: | Gesehen am 21.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1555-8584 |
| DOI: | 10.4161/rna.20481 |