Deregulation of levels of angiopoietin-1 and angiopoietin-2 is associated with severe courses of hantavirus infection
Hantavirus disease is characterized by endothelial dysfunction. Angiopoietin-1 (Ang-1) and its antagonist angiopoietin-2 (Ang-2) play a key role in the control of capillary permeability. Ang-1 is responsible for maintenance of cell-to-cell contacts whereas Ang-2 destabilizes monolayers. An imbalance...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
11 July 2017
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| In: |
Clinical and diagnostic virology
Year: 2017, Volume: 94, Pages: 33-36 |
| ISSN: | 1873-4901 |
| DOI: | 10.1016/j.jcv.2017.07.007 |
| Online Access: | Resolving-System, Volltext: http://dx.doi.org/10.1016/j.jcv.2017.07.007 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1386653217302032 
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| Author Notes: | Christian Nusshag, Anja Osberghaus, Alexandra Baumann, Paul Schnitzler, Martin Zeier, Ellen Krautkrämer |
| Summary: | Hantavirus disease is characterized by endothelial dysfunction. Angiopoietin-1 (Ang-1) and its antagonist angiopoietin-2 (Ang-2) play a key role in the control of capillary permeability. Ang-1 is responsible for maintenance of cell-to-cell contacts whereas Ang-2 destabilizes monolayers. An imbalance of Ang-1 and Ang-2 levels results in enhanced permeability and capillary leakage. To analyze the involvement of angiopoietins in hantavirus-induced disruption of endothelia, we measured the levels of Ang-1 and Ang-2 in hantavirus infection. |
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| Item Description: | Gesehen am 21.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1873-4901 |
| DOI: | 10.1016/j.jcv.2017.07.007 |