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Parenchymal liver blood volume and dynamic volume perfusion CT measurements of hepatocellular carcinoma in patients undergoing transarterial chemoembolization

Aim: Prospective comparison of cone beam C-Arm CT based parenchymal liver blood volume (PLBV) and dynamic volume perfusion CT (dVPCT) measurements in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolisation (TACE) with drug-eluting beads (DEB). Patients and Methods: In...

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Hauptverfasser: Rathmann, Nils-Andreas (VerfasserIn) , Budjan, Johannes (VerfasserIn) , Henzler, Thomas (VerfasserIn) , Smakic, Arman (VerfasserIn) , Schönberg, Stefan (VerfasserIn) , Diehl, Steffen J. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: October 2017
In: Anticancer research
Year: 2017, Jahrgang: 37, Heft: 10, Pages: 5681-5685
ISSN:1791-7530
Online-Zugang:Verlag, teilw. kostenfrei, Volltext: http://ar.iiarjournals.org/content/37/10/5681
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Verfasserangaben:Nils Rathmann, Kerim Kara, Johannes Budjan, Thomas Henzler, Arman Smakic, Stefan O. Schoenberg and Steffen J. Diehl
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Zusammenfassung:Aim: Prospective comparison of cone beam C-Arm CT based parenchymal liver blood volume (PLBV) and dynamic volume perfusion CT (dVPCT) measurements in patients with hepatocellular carcinoma (HCC) undergoing transarterial chemoembolisation (TACE) with drug-eluting beads (DEB). Patients and Methods: In 16 patients, changes of PLBV and dVPCT measurements [arterial liver parenchyma (ALP); temporal maximum intensity projection (MIP); hepatic perfusion index (HPI); portal venous parenchyma] were correlated to one another and to the modified Response Evaluation Criteria in Solid Tumors (mRECIST). Results: After TACE, the following parameters showed a statistically significant change (p<0.05) in mean value: PLBV: −4.85 ml/100 ml, ALP: −4.14 ml/100 ml/min, MIP: −0.23 Houndsfield units, HPI: −5.39%, and mRECIST: −20.53 mm. Pre-to-post TACE differences in PLBV showed only weak to very weak correlation to dVPCT parameters (r2<0.24). Conclusion: Although PLBV and dVPCT parameters showed only a weak to very weak correlation, both methods validly assessed changes in arterial tumor vascularity after DEB TACE.
Beschreibung:Gesehen am 16.04.2020
Beschreibung:Online Resource
ISSN:1791-7530

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