Xenopus paraxial protocadherin inhibits Wnt/β‐catenin signalling via casein kinase 2β

Xenopus paraxial protocadherin (PAPC) regulates cadherin‐mediated cell adhesion and promotes the planar cell polarity (PCP) pathway. Here we report that PAPC functions in the Xenopus gastrula as an inhibitor of the Wnt/β‐catenin pathway. The intracellular domain of PAPC interacts with casein kinase...

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Hauptverfasser: Ciprianidis, Anja (VerfasserIn) , Wang, Yingqun (VerfasserIn) , Weber, Dominik (VerfasserIn) , Steinbeisser, Herbert (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 2012
In: EMBO reports
Year: 2011, Jahrgang: 13, Heft: 2, Pages: 129-134
ISSN:1469-3178
DOI:10.1038/embor.2011.240
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1038/embor.2011.240
Verlag, Volltext: http://embor.embopress.org/content/13/2/129
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Verfasserangaben:Anja Kietzmann, Yingqun Wang, Dominik Weber, Herbert Steinbeisser
Beschreibung
Zusammenfassung:Xenopus paraxial protocadherin (PAPC) regulates cadherin‐mediated cell adhesion and promotes the planar cell polarity (PCP) pathway. Here we report that PAPC functions in the Xenopus gastrula as an inhibitor of the Wnt/β‐catenin pathway. The intracellular domain of PAPC interacts with casein kinase 2 beta (CK2β), which is part of the CK2 holoenzyme. The CK2α/β complex stimulates Wnt/β‐catenin signalling, and the physical interaction of CK2β with PAPC antagonizes this activity. By this mechanism, PAPC restricts the expression of Wnt target genes during gastrulation. These experiments identify a novel function of protocadherins as regulators of the Wnt pathway.
Beschreibung:Published online 23.12.2011
Gesehen am 23.08.2018
Beschreibung:Online Resource
ISSN:1469-3178
DOI:10.1038/embor.2011.240