Xenopus paraxial protocadherin inhibits Wnt/β‐catenin signalling via casein kinase 2β
Xenopus paraxial protocadherin (PAPC) regulates cadherin‐mediated cell adhesion and promotes the planar cell polarity (PCP) pathway. Here we report that PAPC functions in the Xenopus gastrula as an inhibitor of the Wnt/β‐catenin pathway. The intracellular domain of PAPC interacts with casein kinase...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2012
|
| In: |
EMBO reports
Year: 2011, Jahrgang: 13, Heft: 2, Pages: 129-134 |
| ISSN: | 1469-3178 |
| DOI: | 10.1038/embor.2011.240 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/embor.2011.240 Verlag, Volltext: http://embor.embopress.org/content/13/2/129 
|
| Verfasserangaben: | Anja Kietzmann, Yingqun Wang, Dominik Weber, Herbert Steinbeisser |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1580333214 | ||
| 003 | DE-627 | ||
| 005 | 20220814231554.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 180823r20122011xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/embor.2011.240 |2 doi | |
| 035 | |a (DE-627)1580333214 | ||
| 035 | |a (DE-576)510333214 | ||
| 035 | |a (DE-599)BSZ510333214 | ||
| 035 | |a (OCoLC)1341017502 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Ciprianidis, Anja |e VerfasserIn |0 (DE-588)1135303681 |0 (DE-627)890260648 |0 (DE-576)489754805 |4 aut | |
| 245 | 1 | 0 | |a Xenopus paraxial protocadherin inhibits Wnt/β‐catenin signalling via casein kinase 2β |c Anja Kietzmann, Yingqun Wang, Dominik Weber, Herbert Steinbeisser |
| 264 | 1 | |c 2012 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Published online 23.12.2011 | ||
| 500 | |a Gesehen am 23.08.2018 | ||
| 520 | |a Xenopus paraxial protocadherin (PAPC) regulates cadherin‐mediated cell adhesion and promotes the planar cell polarity (PCP) pathway. Here we report that PAPC functions in the Xenopus gastrula as an inhibitor of the Wnt/β‐catenin pathway. The intracellular domain of PAPC interacts with casein kinase 2 beta (CK2β), which is part of the CK2 holoenzyme. The CK2α/β complex stimulates Wnt/β‐catenin signalling, and the physical interaction of CK2β with PAPC antagonizes this activity. By this mechanism, PAPC restricts the expression of Wnt target genes during gastrulation. These experiments identify a novel function of protocadherins as regulators of the Wnt pathway. | ||
| 534 | |c 2011 | ||
| 650 | 4 | |a CK2 | |
| 650 | 4 | |a PAPC | |
| 650 | 4 | |a protocadherin | |
| 650 | 4 | |a Wnt pathway | |
| 650 | 4 | |a Xenopus | |
| 700 | 1 | |a Wang, Yingqun |e VerfasserIn |0 (DE-588)133764753 |0 (DE-627)55576690X |0 (DE-576)300083394 |4 aut | |
| 700 | 1 | |a Weber, Dominik |e VerfasserIn |0 (DE-588)1112156100 |0 (DE-627)86611064X |0 (DE-576)476404738 |4 aut | |
| 700 | 1 | |a Steinbeisser, Herbert |d 1958-2014 |e VerfasserIn |0 (DE-588)1028535325 |0 (DE-627)730898881 |0 (DE-576)167412221 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a European Molecular Biology Organization |t EMBO reports |d [London] : Nature Publishing Group UK, 2000 |g 13(2012), 2, Seite 129-134 |h Online-Ressource |w (DE-627)320645622 |w (DE-600)2025376-X |w (DE-576)095092153 |x 1469-3178 |7 nnas |
| 773 | 1 | 8 | |g volume:13 |g year:2012 |g number:2 |g pages:129-134 |g extent:6 |a Xenopus paraxial protocadherin inhibits Wnt/β‐catenin signalling via casein kinase 2β |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1038/embor.2011.240 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://embor.embopress.org/content/13/2/129 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20180823 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1028535325 |a Steinbeisser, Herbert |m 1028535325:Steinbeisser, Herbert |d 910000 |d 911500 |d 700000 |d 718000 |e 910000PS1028535325 |e 911500PS1028535325 |e 700000PS1028535325 |e 718000PS1028535325 |k 0/910000/ |k 1/910000/911500/ |k 0/700000/ |k 1/700000/718000/ |p 4 |y j | ||
| 998 | |g 1112156100 |a Weber, Dominik |m 1112156100:Weber, Dominik |d 910000 |d 911500 |e 910000PW1112156100 |e 911500PW1112156100 |k 0/910000/ |k 1/910000/911500/ |p 3 | ||
| 998 | |g 133764753 |a Wang, Yingqun |m 133764753:Wang, Yingqun |d 910000 |d 911500 |e 910000PW133764753 |e 911500PW133764753 |k 0/910000/ |k 1/910000/911500/ |p 2 | ||
| 998 | |g 1135303681 |a Ciprianidis, Anja |m 1135303681:Ciprianidis, Anja |d 910000 |d 911500 |e 910000PC1135303681 |e 911500PC1135303681 |k 0/910000/ |k 1/910000/911500/ |p 1 |x j | ||
| 999 | |a KXP-PPN1580333214 |e 3023016380 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Xenopus paraxial protocadherin inhibits Wnt/β‐catenin signalling via casein kinase 2β","title_sort":"Xenopus paraxial protocadherin inhibits Wnt/β‐catenin signalling via casein kinase 2β"}],"person":[{"family":"Ciprianidis","given":"Anja","display":"Ciprianidis, Anja","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Yingqun","family":"Wang","role":"aut","roleDisplay":"VerfasserIn","display":"Wang, Yingqun"},{"given":"Dominik","family":"Weber","role":"aut","display":"Weber, Dominik","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Steinbeisser, Herbert","given":"Herbert","family":"Steinbeisser"}],"note":["Published online 23.12.2011","Gesehen am 23.08.2018"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"1580333214","language":["eng"],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"2012"}],"id":{"doi":["10.1038/embor.2011.240"],"eki":["1580333214"]},"name":{"displayForm":["Anja Kietzmann, Yingqun Wang, Dominik Weber, Herbert Steinbeisser"]},"physDesc":[{"extent":"6 S."}],"relHost":[{"pubHistory":["1.2000 -"],"part":{"pages":"129-134","issue":"2","year":"2012","extent":"6","text":"13(2012), 2, Seite 129-134","volume":"13"},"disp":"European Molecular Biology OrganizationEMBO reports","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 11.03.25"],"recId":"320645622","language":["eng"],"corporate":[{"role":"aut","display":"European Molecular Biology Organization","roleDisplay":"VerfasserIn"}],"title":[{"title_sort":"EMBO reports","title":"EMBO reports"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"[London] ; Heidelberg ; Oxford [u.a.] ; London [u.a.] ; Hoboken, NJ [u.a.]","dateIssuedDisp":"[2000]-","publisher":"Nature Publishing Group UK ; EMBO Press ; Oxford Univ. Press ; Nature Publishing Group ; Wiley"}],"id":{"doi":["10.1002/(ISSN)1469-3178"],"eki":["320645622"],"zdb":["2025376-X"],"issn":["1469-3178"]},"name":{"displayForm":["European Molecular Biology Organization"]}}]} | ||
| SRT | |a CIPRIANIDIXENOPUSPAR2012 | ||