Haemoglobin S and C affect the motion of Maurer's clefts in Plasmodium falciparum-infected erythrocytes
The haemoglobinopathies S and C protect carriers from severe Plasmodium falciparum malaria. We have recently shown that haemoglobin S and C interfere with host-actin remodelling in parasitized erythrocytes and the generation of an actin network that seems to be required for vesicular protein traffic...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2013
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| In: |
Cellular microbiology
Year: 2013, Volume: 15, Issue: 7, Pages: 1111-1126 |
| ISSN: | 1462-5822 |
| DOI: | 10.1111/cmi.12102 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1111/cmi.12102 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.12102 
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| Author Notes: | Nicole Kilian, Martin Dittmer, Marek Cyrklaff, Djeneba Ouermi, Cyrille Bisseye, Jacques Simpore, Friedrich Frischknecht, Cecilia P. Sanchez, Michael Lanzer |
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| 520 | |a The haemoglobinopathies S and C protect carriers from severe Plasmodium falciparum malaria. We have recently shown that haemoglobin S and C interfere with host-actin remodelling in parasitized erythrocytes and the generation of an actin network that seems to be required for vesicular protein trafficking from the Maurer's clefts (a parasite-derived intermediary protein secretory organelle) to the erythrocyte surface. Here we show that the actin network exerts skeletal functions by anchoring the Maurer's clefts within the erythrocyte cytoplasm. Using a customized tracking tool to investigate the motion of single Maurer's clefts, we found that a functional actin network restrains Brownian motion of this organelle. Maurer's clefts moved significantly faster in wild-type erythrocytes treated with the actin depolymerizing agent cytochalasin D and in erythrocytes containing the haemoglobin variants S and C. Our data support the model of an impaired actin network being an underpinning cause of cellular malfunctioning in parasitized erythrocytes containing haemoglobin S or C, and, possibly, for the protective role of these haemoglobin variants against severe malaria. | ||
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