The giant protein titin regulates the length of the striated muscle thick filament
Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice.
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| Autori principali: | , |
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| Natura: | Article (Journal) |
| Lingua: | inglese |
| Pubblicazione: |
19 October 2017
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| In: |
Nature Communications
Year: 2017, Volume: 8 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-017-01144-9 |
| Accesso online: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-017-01144-9
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| Note sull'autore: | Paola Tonino, Balazs Kiss, Josh Strom, Mei Methawasin, John E. Smith, Justin Kolb, Siegfried Labeit and Henk Granzier |
| Riassunto: | Thick filaments in skeletal muscle and heart are composed of myosin. The authors show that the length of thick filaments is defined by titin, and that alterations in titin length affect force generation and lead to dilated cardiomyopathy in mice. |
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| Descrizione del documento: | Gesehen am 28.08.2018 |
| Descrizione fisica: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-017-01144-9 |