Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond
Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging Zika virus, are an increasing and probably lasting global risk. This Review summarizes and comments on the opportunities for broad-spectrum agents that are active against multiple flaviviruses. Broad-spectrum...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 May 2017
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| In: |
Nature reviews. Drug discovery
Year: 2017, Volume: 16, Issue: 8, Pages: 565-586 |
| ISSN: | 1474-1784 |
| DOI: | 10.1038/nrd.2017.33 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1038/nrd.2017.33 Verlag, Volltext: https://www.nature.com/articles/nrd.2017.33 
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| Author Notes: | Veaceslav Boldescu, Mira A.M. Behnam, Nikos Vasilakis, Christian D. Klein |
| Summary: | Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging Zika virus, are an increasing and probably lasting global risk. This Review summarizes and comments on the opportunities for broad-spectrum agents that are active against multiple flaviviruses. Broad-spectrum activity is particularly desirable to prepare for the next flaviviral epidemic, which could emerge from as-yet unknown or neglected viruses. Potential molecular targets for broad-spectrum antiflaviviral compounds include viral proteins, such as the viral protease or polymerase, and host targets that are exploited by these viruses during entry and replication, including α-glucosidase and proteins involved in nucleoside biosynthesis. Numerous compounds with broad-spectrum antiviral activity have already been identified by target-specific or phenotypic assays. For other compounds, broad-spectrum activity can be anticipated because of their mode of action and molecular targets. |
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| Item Description: | Gesehen am 29.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1474-1784 |
| DOI: | 10.1038/nrd.2017.33 |