Interleukin-1R signaling is essential for induction of proapoptotic cd8 t cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice
The T cell granule exocytosis pathway is essential to control hepatotropic lymphocytic choriomeningitis virus strain WE (LCMV-WE) but also contributes to the observed pathology in mice. Although effective antiviral T cell immunity and development of viral hepatitis are strictly dependent on perforin...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
6 June 2012
|
| In: |
Journal of virology
Year: 2012, Volume: 86, Issue: 16, Pages: 8713-8719 |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/JVI.00682-12 |
| Online Access: | Verlag, kostenfrei, Volltext: https://jvi.asm.org/content/86/16/8713 Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1128/JVI.00682-12 
|
| Author Notes: | Lars T. Joeckel, Reinhard Wallich, Sunil S. Metkar, Christopher J. Froelich, Markus M. Simon, and Christoph Borner |
| Summary: | The T cell granule exocytosis pathway is essential to control hepatotropic lymphocytic choriomeningitis virus strain WE (LCMV-WE) but also contributes to the observed pathology in mice. Although effective antiviral T cell immunity and development of viral hepatitis are strictly dependent on perforin and granzymes, the molecular basis underlying induction of functionally competent virus-immune T cells, including participation of the innate immune system, is far from being resolved. We demonstrate here that LCMV-immune T cells of interleukin-1 receptor (IL-1R)-deficient mice readily express transcripts for perforin and granzymes but only translate perforin, resulting in the lack of proapoptotic potential in vitro. LCMV is not cleared in IL-1R-deficient mice, and yet the infected mice develop neither splenomegaly nor hepatitis. These results demonstrate that IL-1R signaling is central to the induction of proapoptotic CD8 T cell immunity, including viral clearance and associated tissue injuries in LCMV infection. |
|---|---|
| Item Description: | Published ahead of print 6 June 2012 Gesehen am 30.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1098-5514 |
| DOI: | 10.1128/JVI.00682-12 |