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Interleukin-1R signaling is essential for induction of proapoptotic cd8 t cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice

The T cell granule exocytosis pathway is essential to control hepatotropic lymphocytic choriomeningitis virus strain WE (LCMV-WE) but also contributes to the observed pathology in mice. Although effective antiviral T cell immunity and development of viral hepatitis are strictly dependent on perforin...

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Bibliographic Details
Main Authors: Jöckel, Lars Thomas (Author) , Wallich, Reinhard (Author)
Format: Article (Journal)
Language:English
Published: 6 June 2012
In: Journal of virology
Year: 2012, Volume: 86, Issue: 16, Pages: 8713-8719
ISSN:1098-5514
DOI:10.1128/JVI.00682-12
Online Access:Verlag, kostenfrei, Volltext: https://jvi.asm.org/content/86/16/8713
Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1128/JVI.00682-12
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Author Notes:Lars T. Joeckel, Reinhard Wallich, Sunil S. Metkar, Christopher J. Froelich, Markus M. Simon, and Christoph Borner

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520 |a The T cell granule exocytosis pathway is essential to control hepatotropic lymphocytic choriomeningitis virus strain WE (LCMV-WE) but also contributes to the observed pathology in mice. Although effective antiviral T cell immunity and development of viral hepatitis are strictly dependent on perforin and granzymes, the molecular basis underlying induction of functionally competent virus-immune T cells, including participation of the innate immune system, is far from being resolved. We demonstrate here that LCMV-immune T cells of interleukin-1 receptor (IL-1R)-deficient mice readily express transcripts for perforin and granzymes but only translate perforin, resulting in the lack of proapoptotic potential in vitro. LCMV is not cleared in IL-1R-deficient mice, and yet the infected mice develop neither splenomegaly nor hepatitis. These results demonstrate that IL-1R signaling is central to the induction of proapoptotic CD8 T cell immunity, including viral clearance and associated tissue injuries in LCMV infection. 
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