Striatal structure and its association with N-Acetylaspartate and glutamate in autism spectrum disorder and obsessive compulsive disorder
Autism spectrum disorders (ASD) and obsessive compulsive disorder (OCD) are often comorbid and are associated with changes in striatal volumes and N-Acetylaspartate (NAA) and glutamate levels. Here, we investigated the relation between dorsal striatal volume and NAA and glutamate levels. We addition...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
European neuropsychopharmacology
Year: 2017, Volume: 28, Issue: 1, Pages: 118-129 |
| ISSN: | 1873-7862 |
| DOI: | 10.1016/j.euroneuro.2017.11.010 |
| Online Access: | Verlag, Pay-per-use, Volltext: http://dx.doi.org/10.1016/j.euroneuro.2017.11.010 Verlag, Pay-per-use, Volltext: http://www.sciencedirect.com/science/article/pii/S0924977X17320011 
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| Author Notes: | Jilly Naaijen, Marcel P. Zwiers, Natalie J. Forde, Steven CR Williams, Sarah Durston, Daniel Brandeis, Jeffrey C. Glennon, The TACTICS consortium, Barbara Franke, David J. Lythgoe, Jan K. Buitelaar |
| Summary: | Autism spectrum disorders (ASD) and obsessive compulsive disorder (OCD) are often comorbid and are associated with changes in striatal volumes and N-Acetylaspartate (NAA) and glutamate levels. Here, we investigated the relation between dorsal striatal volume and NAA and glutamate levels. We additionally compared striatal volume and shape between ASD, OCD and controls. T1-weighted magnetic resonance (MR) images, proton spectra (1H-MRS) in the left striatum, and phenotypic information were collected from 54 children with ASD, 32 with OCD, and 56 controls (aged 8-13 years) in a four-site study. Dorsal striatal volume and shape were determined using the FMRIB integrated registration and segmentation tool (FIRST). Spectra were processed with Linear Combination Model. The relationship of left striatal volume with NAA and glutamate was investigated, and group comparisons were performed for NAA levels and for bilateral striatal volume and shape. NAA levels were lower in subjects with ASD compared with controls (t=2.86, p=0.005) and were associated with striatal volume (β=0.37, t=2.78, p=0.008). Glutamate levels were also associated with volume in the ASD group (β=0.38, t=2.46, p=0.018). No group differences were found for striatal volume or shape, but a post-hoc diagnosis-by-hemisphere interaction (F(2,129)=3.86, p=0.024) revealed greater asymmetry (right>left) in striatal volume for the disorder-groups compared with controls. Our findings show involvement of NAA and glutamate in striatal volume in ASD and suggest greater asymmetry in paediatric ASD and OCD compared with controls, pointing to overlapping subcortical abnormalities. The lower NAA in ASD reflects reduced neuronal integrity or impaired neuronal functioning. |
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| Item Description: | Available online 21 November 2017 Gesehen am 30.08.2018 Daniel Brandeis is a member of the TACTICS consortium |
| Physical Description: | Online Resource |
| ISSN: | 1873-7862 |
| DOI: | 10.1016/j.euroneuro.2017.11.010 |