SUMO unloads the Kap114 cab
Nucleocytoplasmic transport is an essential mechanism in all eukaryotic cells, for which the basic mechanisms seemed well understood. Transport receptors of the importin b/karyopherin family recognize, translocate and discharge cargo. Key to directed transport is the GTPase Ran, which determines com...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 May 2012
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| In: |
The EMBO journal
Year: 2012, Volume: 31, Issue: 11, Pages: 2439-2440 |
| ISSN: | 1460-2075 |
| DOI: | 10.1038/emboj.2012.103 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/emboj.2012.103 Verlag, kostenfrei, Volltext: https://www.embopress.org/doi/full/10.1038/emboj.2012.103 
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| Author Notes: | Andreas Werner and Frauke Melchior |
| Summary: | Nucleocytoplasmic transport is an essential mechanism in all eukaryotic cells, for which the basic mechanisms seemed well understood. Transport receptors of the importin b/karyopherin family recognize, translocate and discharge cargo. Key to directed transport is the GTPase Ran, which determines compartment-specific interactions between receptors and their cargo. In this issue of The EMBO Journal, Rothenbusch et al (2012) now add a new energy-dependent event to this basic pathway by providing direct evidence that the posttranslational modification of the yeast import receptor Kap114 with small ubiquitin-related modifier (SUMO) is indispensable for its correct function. An exciting model emerges in which Kap114 sumoylation regulates Ran-dependent cargo release, and thereby acts as a mechanism for intranuclear targeting of the import cargo. |
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| Item Description: | Gesehen am 31.08.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1460-2075 |
| DOI: | 10.1038/emboj.2012.103 |