Indocyanine green fluorescence imaging in hepatobiliary surgery
Indocyanine green (ICG) is a fluorescent dye that has been widely used for fluorescence imaging during hepatobiliary surgery. ICG is injected intravenously, selectively taken up by the liver, and then secreted into the bile. The catabolism and fluorescence properties of ICG permit a wide range of vi...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
Photodiagnosis and photodynamic therapy
Year: 2016, Volume: 17, Pages: 208-215 |
| ISSN: | 1873-1597 |
| DOI: | 10.1016/j.pdpdt.2016.12.005 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.pdpdt.2016.12.005 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1572100016302411 
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| Author Notes: | Ali Majlesara, Mohammad Golriz, Mohammadreza Hafezi, Arash Saffari, Esther Stenau, Lena Maier-Hein, Beat P. Müller-Stich, Arianeb Mehrabi |
| Summary: | Indocyanine green (ICG) is a fluorescent dye that has been widely used for fluorescence imaging during hepatobiliary surgery. ICG is injected intravenously, selectively taken up by the liver, and then secreted into the bile. The catabolism and fluorescence properties of ICG permit a wide range of visualization methods in hepatobiliary surgery. We have characterized the applications of ICG during hepatobiliary surgery into: 1) liver mapping, 2) cholangiography, 3) tumor visualization, and 4) partial liver graft evaluation. In this literature review, we summarize the current understanding of ICG use during hepatobiliary surgery. Intra-operative ICG fluorescence imaging is a safe, simple, and feasible method that improves the visualization of hepatobiliary anatomy and liver tumors. Intravenous administration of ICG is not toxic and avoids the drawbacks of conventional imaging. In addition, it reduces post-operative complications without any known side effects. ICG fluorescence imaging provides a safe and reliable contrast for extra-hepatic cholangiography when detecting intra-hepatic bile leakage following liver resection. In addition, liver tumors can be visualized and well-differentiated hepatocellular carcinoma tumors can be accurately identified. Moreover, vascular reconstruction and outflow can be evaluated following partial liver transplantation. However, since tissue penetration is limited to 5-10mm, deeper tissue cannot be visualized using this method. Many instances of false positive or negative results have been reported, therefore further characterization is required. |
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| Item Description: | available online 23 December 2016 Gesehen am 03.09.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1873-1597 |
| DOI: | 10.1016/j.pdpdt.2016.12.005 |