High-density peptide arrays for Malaria vaccine development
The development of an efficacious and practicable vaccine conferring sterile immunity towards a Plasmodium infection represents a not yet achieved goal. A crucial factor for the impact of a given anti-plasmodial subunit vaccine is the identification of the most potent parasitic components required t...
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| Main Authors: | , , |
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| Format: | Chapter/Article |
| Language: | English |
| Published: |
14 April 2016
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| In: |
Vaccine design
Year: 2016, Pages: 569-582 |
| DOI: | 10.1007/978-1-4939-3387-7_32 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1007/978-1-4939-3387-7_32
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| Author Notes: | Felix F. Loeffler, Johannes Pfeil, Kirsten Heiss |
| Summary: | The development of an efficacious and practicable vaccine conferring sterile immunity towards a Plasmodium infection represents a not yet achieved goal. A crucial factor for the impact of a given anti-plasmodial subunit vaccine is the identification of the most potent parasitic components required to induce protection from both infection and disease. Here, we present a method based on a novel high-density peptide array technology that allows for a flexible readout of malaria antibodies. Peptide arrays applied as a screening method can be used to identify novel immunogenic antibody epitopes under a large number of potential antigens/peptides. Ultimately, discovered antigen candidates and/or epitope sequences can be translated into vaccine prototype design. The technology can be further utilized to unravel antibody-mediated immune responses (e.g., involved in the establishment of semi-immunity) and moreover to confirm vaccine potency during the process of clinical development by verifying the induced antibody responses following vaccination. |
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| Item Description: | Gesehen am 04.09.2018 |
| Physical Description: | Online Resource |
| ISBN: | 9781493933877 |
| DOI: | 10.1007/978-1-4939-3387-7_32 |