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High-density peptide arrays for Malaria vaccine development

The development of an efficacious and practicable vaccine conferring sterile immunity towards a Plasmodium infection represents a not yet achieved goal. A crucial factor for the impact of a given anti-plasmodial subunit vaccine is the identification of the most potent parasitic components required t...

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Hauptverfasser: Löffler, Felix (VerfasserIn) , Pfeil, Johannes (VerfasserIn) , Heiß, Kirsten (VerfasserIn)
Dokumenttyp: Kapitel/Artikel
Sprache:Englisch
Veröffentlicht: 14 April 2016
In: Vaccine design
Year: 2016, Pages: 569-582
DOI:10.1007/978-1-4939-3387-7_32
Online-Zugang:Verlag, Volltext: http://dx.doi.org/10.1007/978-1-4939-3387-7_32
Volltext
Verfasserangaben:Felix F. Loeffler, Johannes Pfeil, Kirsten Heiss

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520 |a The development of an efficacious and practicable vaccine conferring sterile immunity towards a Plasmodium infection represents a not yet achieved goal. A crucial factor for the impact of a given anti-plasmodial subunit vaccine is the identification of the most potent parasitic components required to induce protection from both infection and disease. Here, we present a method based on a novel high-density peptide array technology that allows for a flexible readout of malaria antibodies. Peptide arrays applied as a screening method can be used to identify novel immunogenic antibody epitopes under a large number of potential antigens/peptides. Ultimately, discovered antigen candidates and/or epitope sequences can be translated into vaccine prototype design. The technology can be further utilized to unravel antibody-mediated immune responses (e.g., involved in the establishment of semi-immunity) and moreover to confirm vaccine potency during the process of clinical development by verifying the induced antibody responses following vaccination. 
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