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Sehr schweres Differenzierungssyndrom bei Niedrigrisiko akuter Promyelozytenleukämie - eine Tücke der differenzierenden Therapie = Very severe differentiation syndrome in low risk acute promyelocytic leukemia - a peril of differentiating therapy

History, examinations and diagnosis: A young patient consulted the hospital because of spontaneous hematomas. The combination of pancytopenia and coagulopathy in the blood and the proving cytogenetic and moleculargenetic examinations of the bone marrow lead to the diagnosis of low-risk acute promyel...

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Bibliographic Details
Main Authors: Hecht, Anna (Author) , Lengfelder, Eva (Author)
Format: Article (Journal)
Language:German
Published: 23. Januar 2017
In: Deutsche medizinische Wochenschrift
Year: 2017, Volume: 142, Issue: 02, Pages: 111-114
ISSN:1439-4413
DOI:10.1055/s-0042-121365
Online Access:Verlag, Volltext: http://dx.doi.org/10.1055/s-0042-121365
Verlag, Volltext: http://www.thieme-connect.de.ezproxy.medma.uni-heidelberg.de/DOI/DOI?10.1055/s-0042-121365
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Author Notes:Anna Hecht, Joerg Mezger, Martina Gnadler, Eva Lengfelder
Description
Summary:History, examinations and diagnosis: A young patient consulted the hospital because of spontaneous hematomas. The combination of pancytopenia and coagulopathy in the blood and the proving cytogenetic and moleculargenetic examinations of the bone marrow lead to the diagnosis of low-risk acute promyelocytic leukemia (APL). Therapy and clinical course: During the combination therapy with ATRA and ATO, the patient developed a severe differentiation syndrome and hyperleukocytosis. Management of the condition was only possible due to clinical expertise and massive substitution of blood products and clotting factors. Conclusion: The case illustrates the difficulty and dangers of APL induction therapy even with a favorable initial clinical presentation despite the generally low toxicity of new therapies.
Item Description:Gesehen am 05.09.2018
Physical Description:Online Resource
ISSN:1439-4413
DOI:10.1055/s-0042-121365

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