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Patent foramen ovale and cryptogenic strokes in the stroke in young fabry patients study

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Background and Purpose: A patent foramen ovale (PFO) is disproportionately prevalent in patients with cryptogenic stroke. Without alternative explanations, it is frequently considered to be causative. A detailed stratification of these patients may improve the identification of incidental PFO. Metho...

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Main Authors: Huber, Roman (Author) , Grittner, Ulrike (Author) , Weidemann, Frank (Author) , Thijs, Vincent (Author) , Tanislav, Christian (Author) , Enzinger, Christian (Author) , Fazekas, Franz (Author) , Wolf, Markus (Author) , Hennerici, Michael G. (Author) , McCabe, Dominick J. H. (Author) , Putaala, Jukaa (Author) , Tatlisumak, Turgut (Author) , Kessler, Christoph (Author) , Sarnowski, Bettina von (Author) , Martus, Peter (Author) , Kolodny, Edwin (Author) , Norrving, Bo (Author) , Rolfs, Arndt (Author)
Format: Article (Journal)
Language:English
Published: 2017
In: Stroke
Year: 2017, Volume: 48, Issue: 1, Pages: 30-35
ISSN:1524-4628
DOI:10.1161/STROKEAHA.116.013620
Online Access:Verlag, Volltext: http://dx.doi.org/10.1161/STROKEAHA.116.013620
Verlag, Volltext: https://www-ahajournals-org.ezproxy.medma.uni-heidelberg.de/doi/10.1161/STROKEAHA.116.013620
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Author Notes:Roman Huber, MD; Ulrike Grittner, PhD; Frank Weidemann, MD; Vincent Thijs, MD, PhD; Christian Tanislav, MD; Christian Enzinger, MD; Franz Fazekas, MD; Markus Wolf, MD; Michael G. Hennerici, MD, PhD; Dominick J.H. McCabe, PhD; Jukaa Putaala, MD, PhD, MSc; Turgut Tatlisumak, MD, PhD; Christoph Kessler, MD; Bettina von Sarnowski, MD; Peter Martus, PhD; Edwin Kolodny, MD; Bo Norrving, MD, PhD; Arndt Rolfs, MD; on behalf of the Stroke in Young Fabry Patients (SIFAP) Investigators
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Summary:Background and Purpose: A patent foramen ovale (PFO) is disproportionately prevalent in patients with cryptogenic stroke. Without alternative explanations, it is frequently considered to be causative. A detailed stratification of these patients may improve the identification of incidental PFO. Methods: We investigated the PFO prevalence in 3497 transient ischemic attack and ischemic stroke patients aged 18 to 55 years in the prospective multicenter SIFAP1 study (Stroke in Young Fabry Patients 1) using the ASCO classification. Patients without an obvious cause for transient ischemic attack/stroke (ASCO 0) were divided into subgroups with and without vascular risk factors (ASCO 0+ and 0−). In addition, we looked for PFO-related magnetic resonance imaging lesion patterns. Results: PFO was identified in 25% of patients. Twenty percent of patients with a definite or probable cause of transient ischemic attack/stroke (≥1 grade 1 or 2 ASCO criterion; n=1769) had a PFO compared with 29% of cryptogenic stroke patient...
Item Description:Originally published: 29 Nov 2016
Gesehen am 05.09.2018
Physical Description:Online Resource
ISSN:1524-4628
DOI:10.1161/STROKEAHA.116.013620

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