Optimizing conditions for labeling of mesenchymal stromal cells (MSCs) with gold nanoparticles: a prerequisite for in vivo tracking of MSCs
Mesenchymal stromal cells (MSCs) have an inherent migratory capacity towards tumor tissue in vivo. With the future objective to quantify the tumor homing efficacy of MSCs, as first step in this direction we investigated the use of inorganic nanoparticles (NPs), in particular ca. 4 nm-sized Au NPs, f...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
29 March 2017
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| In: |
Journal of nanobiotechnology
Year: 2017, Volume: 15, Issue: 1, Pages: 24 |
| ISSN: | 1477-3155 |
| DOI: | 10.1186/s12951-017-0258-5 |
| Online Access: | Resolving-System, kostenfrei, Volltext: http://dx.doi.org/10.1186/s12951-017-0258-5 Verlag, kostenfrei, Volltext: https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-017-0258-5 
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| Author Notes: | Philipp Nold, Raimo Hartmann, Neus Feliu, Karsten Kantner, Mahmoud Gamal, Beatriz Pelaz, Jonas Hühn, Xing Sun, Philipp Jungebluth, Pablo del Pino, Holger Hackstein, Paolo Macchiarini, Wolfgang J. Parak and Cornelia Brendel |
| Summary: | Mesenchymal stromal cells (MSCs) have an inherent migratory capacity towards tumor tissue in vivo. With the future objective to quantify the tumor homing efficacy of MSCs, as first step in this direction we investigated the use of inorganic nanoparticles (NPs), in particular ca. 4 nm-sized Au NPs, for MSC labeling. Time dependent uptake efficiencies of NPs at different exposure concentrations and times were determined via inductively coupled plasma mass spectrometry (ICP-MS). |
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| Item Description: | Gesehen am 04.12.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1477-3155 |
| DOI: | 10.1186/s12951-017-0258-5 |