Diastereoselective synthesis of functionalized diketopiperazines through post-transformational reactions
A diversity-oriented access to diastereoselective arylidene 2,5-diketopiperazines is elaborated via a sequential Ugi post-transformation involving catalytic cyclization and oxidative Heck reaction sequence. This sequence offers an interesting multicomponent entry to a library of 2,5-diketopiperazine...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
October 19, 2017
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| In: |
The journal of organic chemistry
Year: 2017, Volume: 82, Issue: 23, Pages: 12141-12152 |
| ISSN: | 1520-6904 |
| DOI: | 10.1021/acs.joc.7b01855 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1021/acs.joc.7b01855 Verlag, Volltext: https://doi.org/10.1021/acs.joc.7b01855 
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| Author Notes: | Saeed Balalaie, Reihaneh Ramezani Kejani, Elmira Ghabraie, Fatemeh Darvish, Frank Rominger, Fatima Hamdan, and Hamid Reza Bijanzadeh |
| Summary: | A diversity-oriented access to diastereoselective arylidene 2,5-diketopiperazines is elaborated via a sequential Ugi post-transformation involving catalytic cyclization and oxidative Heck reaction sequence. This sequence offers an interesting multicomponent entry to a library of 2,5-diketopiperazines and arylidene 2,5-diketopiperazines under mild reaction conditions in good to excellent yields. |
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| Item Description: | Gesehen am 06.09.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1520-6904 |
| DOI: | 10.1021/acs.joc.7b01855 |