Effective downsizing but enhanced intratumoral heterogeneity following neoadjuvant sorafenib in patients with non-metastatic renal cell carcinoma

Objectives To evaluate the safety and feasibility of sorafenib prior to surgery for downsizing tumors in patients with nonmetastatic cT1-3 renal tumors together with a characterization of functional intratumoral heterogeneity (ITH).

Bibliographic Details

Main Authors:	Hatiboglu, Gencay (Author) , Hohenfellner, Markus (Author) , Arslan, Aysenur (Author) , Hadaschik, Boris (Author) , Teber, Dogu (Author) , Radtke, Jan Philipp (Author) , Hallscheidt, Peter (Author) , Tolstov, Yanis (Author) , Roth, Wilfried (Author) , Grüllich, Carsten (Author) , Hüsing, Johannes (Author) , Duensing, Stefan (Author) , Pahernik, Sascha (Author)
Format:	Article (Journal)
Language:	English
Published:	2017
In:	Langenbeck's archives of surgery Year: 2017, Volume: 402, Issue: 4, Pages: 637-644
ISSN:	1435-2451
DOI:	10.1007/s00423-016-1543-8
Online Access:	Verlag, Volltext: http://dx.doi.org/10.1007/s00423-016-1543-8 Verlag, Volltext: http://link.springer.com/10.1007/s00423-016-1543-8
Author Notes:	Gencay Hatiboglu, Markus Hohenfellner, Aysenur Arslan, Boris Hadaschik, Dogu Teber, Jan Philipp Radtke, Peter Hallscheidt, Yanis Tolstov, Wilfried Roth, Carsten Grüllich, Johannes Huesing, Stefan Duensing, Sascha Pahernik