Advances in stem cell proteomics
Stem cells are at the basis of organismal development, characterized by their potential to differentiate towards specific lineages upon receiving proper signals. To understand the molecular principles underlying gain and loss of pluripotency, proteomics plays an increasingly important role owing to...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
11th August 2017
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| In: |
Current opinion in genetics & development
Year: 2017, Volume: 46, Pages: 149-155 |
| ISSN: | 1879-0380 |
| DOI: | 10.1016/j.gde.2017.07.007 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.gde.2017.07.007 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0959437X17300199 
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| Author Notes: | Nade Abazova and Jeroen Krijgsveld |
| Summary: | Stem cells are at the basis of organismal development, characterized by their potential to differentiate towards specific lineages upon receiving proper signals. To understand the molecular principles underlying gain and loss of pluripotency, proteomics plays an increasingly important role owing to technical developments in mass spectrometry and implementation of innovative biochemical approaches. Here we review how quantitative proteomics has been used to investigate protein expression, localization, interaction and modification in stem cells both in vitro and in vivo, thereby complementing other omics approaches to study fundamental properties of stem cell plasticity. |
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| Item Description: | Gesehen am 12.09.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1879-0380 |
| DOI: | 10.1016/j.gde.2017.07.007 |