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Chronic viral hepatitis and its association with liver cancer

Chronic infection with hepatitis viruses represents the major causative factor for end-stage liver diseases, including liver cirrhosis and primary liver cancer (hepatocellular carcinoma, HCC). In this review, we highlight the current understanding of the molecular mechanisms that drive the hepatocar...

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Bibliographic Details
Main Authors: Tu, Thomas (Author) , Bühler, Sandra (Author) , Bartenschlager, Ralf (Author)
Format: Article (Journal)
Language:English
Published: 29.04.2017
In: Biological chemistry
Year: 2017, Volume: 398, Issue: 8, Pages: 817-837
ISSN:1437-4315
DOI:10.1515/hsz-2017-0118
Online Access:Verlag, Pay-per-use, Volltext: http://dx.doi.org/10.1515/hsz-2017-0118
Verlag, Pay-per-use, Volltext: https://www.degruyterbrill.com/view/j/bchm.2017.398.issue-8/hsz-2017-0118/hsz-2017-0118.xml
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Author Notes:Thomas Tu, Sandra Bühler, Ralf Bartenschlager
Description
Summary:Chronic infection with hepatitis viruses represents the major causative factor for end-stage liver diseases, including liver cirrhosis and primary liver cancer (hepatocellular carcinoma, HCC). In this review, we highlight the current understanding of the molecular mechanisms that drive the hepatocarcinogenesis associated with chronic hepatitis virus infections. While chronic inflammation (associated with a persistent, but impaired anti-viral immune response) plays a major role in HCC initiation and progression, hepatitis viruses can also directly drive liver cancer. The mechanisms by which hepatitis viruses induce HCC include: hepatitis B virus DNA integration into the host cell genome; metabolic reprogramming by virus infection; induction of the cellular stress response pathway by viral gene products; and interference with tumour suppressors. Finally, we summarise the limitations of hepatitis virus-associated HCC model systems and the development of new techniques to circumvent these shortcomings.
Item Description:Gesehen am 12.09.2018
Physical Description:Online Resource
ISSN:1437-4315
DOI:10.1515/hsz-2017-0118

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