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Frontostriatal connectivity during reward anticipation: a neurobiological mechanism cutting across alcohol use disorder and depression?

. Neurobiological research indicates that altered reward processing is among the most promising risk mechanisms in alcohol use disorder and depression. To elucidate differences and similarities between both disorders, we investigated clinical patients and at-risk individuals in two studies using a f...

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Main Authors: Becker, Alena (Author) , Gerchen, Martin Fungisai (Author) , Kirsch, Martina (Author) , Rachota-Ubl, Bettina (Author) , Diener, Carsten (Author) , Kühner, Christine (Author) , Kiefer, Falk (Author) , Kirsch, Peter (Author)
Format: Article (Journal)
Language:English
Published: November 30, 2017
In: Zeitschrift für Psychologie
Year: 2017, Volume: 225, Issue: 3, Pages: 232-243
ISSN:2151-2604
DOI:10.1027/2151-2604/a000307
Online Access:Verlag, Volltext: http://dx.doi.org/10.1027/2151-2604/a000307
Verlag, Volltext: https://econtent.hogrefe.com/doi/10.1027/2151-2604/a000307
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Author Notes:Alena Becker, Martin Fungisai Gerchen, Martina Kirsch, Bettina Ubl, Sivaniya Subramaniapillai, Carsten Diener, Christine Kuehner, Falk Kiefer and Peter Kirsch
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Summary:. Neurobiological research indicates that altered reward processing is among the most promising risk mechanisms in alcohol use disorder and depression. To elucidate differences and similarities between both disorders, we investigated clinical patients and at-risk individuals in two studies using a functional magnetic resonance imaging (fMRI) monetary reward paradigm. In the first study, alcohol use disorder patients compared to depressed and healthy individuals showed increased activation of the ventral striatum during reward anticipation. In contrast, both patient groups showed reduced frontostriatal connectivity compared to controls. In the second study, at-risk comorbid individuals showed decreased activation in the dorsal striatum along with decreased frontostriatal connectivity. While the connectivity results replicate the common pattern found for the patient groups, the activation results indicate a more depression-related pattern in individuals prone to developing both disorders. In conclusion, frontostriatal connectivity might be a promising transdiagnostic marker for depression, alcohol use disorder, and their comorbidity.
Item Description:Gesehen am 13.09.2018
Physical Description:Online Resource
ISSN:2151-2604
DOI:10.1027/2151-2604/a000307

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