Interobserver variation among pathologists and refinement of criteria in distinguishing separate primary tumors from intrapulmonary metastases in lung
Multiple tumor nodules are seen with increasing frequency in clinical practice. On the basis of the 2015 WHO classification of lung tumors, we assessed the reproducibility of the comprehensive histologic assessment to distinguish second primary lung cancers (SPLCs) from intrapulmonary metastases (IP...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018
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| In: |
Journal of thoracic oncology
Year: 2017, Volume: 13, Issue: 2, Pages: 205-217 |
| ISSN: | 1556-1380 |
| DOI: | 10.1016/j.jtho.2017.10.019 |
| Online Access: | Resolving-System, Volltext: http://dx.doi.org/10.1016/j.jtho.2017.10.019 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1556086417328630 
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| Author Notes: | Andrew G. Nicholson, Kathleen Torkko, Patrizia Viola, Edwina Duhig, Kim Geisinger, Alain C. Borczuk, Kenzo Hiroshima, Ming S. Tsao, Arne Warth, Sylvie Lantuejoul, Prudence A. Russell, Erik Thunnissen, Alberto Marchevsky, Mari Mino-Kenudson, Mary Beth Beasley, Johan Botling, Sanja Dacic, Yasushi Yatabe, Masayuki Noguchi, William D. Travis, Keith Kerr, Fred R. Hirsch, Lucian R. Chirieac, Ignacio I. Wistuba, Andre Moreira, Jin-Haeng Chung, Teh Ying Chou, Lukas Bubendorf, Gang Chen, Giuseppe Pelosi, Claudia Poleri, Frank C. Detterbeck, Wilbur A. Franklin |
| Summary: | Multiple tumor nodules are seen with increasing frequency in clinical practice. On the basis of the 2015 WHO classification of lung tumors, we assessed the reproducibility of the comprehensive histologic assessment to distinguish second primary lung cancers (SPLCs) from intrapulmonary metastases (IPMs), looking for the most distinctive histologic features. An international panel of lung pathologists reviewed a scanned sequential cohort of 126 tumors from 48 patients and recorded an agreed set of histologic features, including tumor typing and predominant pattern of adenocarcinoma, thereby opining whether the case was SPLC, IPM, or a combination thereof. |
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| Item Description: | Available online: 7 November 2017 Gesehen am 13.09.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1556-1380 |
| DOI: | 10.1016/j.jtho.2017.10.019 |