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Validation of T-Track® CMV to assess the functionality of cytomegalovirus-reactive cell-mediated immunity in hemodialysis patients

Uncontrolled cytomegalovirus (CMV) replication in immunocompromised solid-organ transplant recipients is a clinically relevant issue and an indication of impaired CMV-specific cell-mediated immunity (CMI). Primary aim of this study was to assess the suitability of the immune monitoring tool T-Track®...

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Bibliographic Details
Main Authors: Banas, Bernhard (Author) , Krüger, Bernd (Author) , Krämer, Bernhard (Author)
Format: Article (Journal)
Language:English
Published: 7 March 2017
In: BMC immunology
Year: 2017, Volume: 18
ISSN:1471-2172
DOI:10.1186/s12865-017-0194-z
Online Access:Verlag, Volltext: http://dx.doi.org/10.1186/s12865-017-0194-z
Verlag, Volltext: https://doi.org/10.1186/s12865-017-0194-z
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Author Notes:Bernhard Banas, Carsten A. Böger, Gerhard Lückhoff, Bernd Krüger, Sascha Barabas, Julia Batzilla, Mathias Schemmerer, Josef Köstler, Hanna Bendfeldt, Anne Rascle, Ralf Wagner, Ludwig Deml, Joachim Leicht and Bernhard K. Krämer
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Summary:Uncontrolled cytomegalovirus (CMV) replication in immunocompromised solid-organ transplant recipients is a clinically relevant issue and an indication of impaired CMV-specific cell-mediated immunity (CMI). Primary aim of this study was to assess the suitability of the immune monitoring tool T-Track® CMV to determine CMV-reactive CMI in a cohort of hemodialysis patients representative of patients eligible for renal transplantation. Positive and negative agreement of T-Track® CMV with CMV serology was examined in 124 hemodialysis patients, of whom 67 (54%) revealed a positive CMV serostatus. Secondary aim of the study was to evaluate T-Track® CMV performance against two unrelated CMV-specific CMI monitoring assays, QuantiFERON®-CMV and a cocktail of six class I iTAg™ MHC Tetramers.
Item Description:Published: 7 March 2017
Gesehen am 14.09.2018
Physical Description:Online Resource
ISSN:1471-2172
DOI:10.1186/s12865-017-0194-z

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