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Genetic predisposition to multiple myeloma at 5q15 is mediated by an ELL2 enhancer polymorphism

Summary - Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by which it influences tumorigenesis. We show that rs6877329 G > C r...

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Main Authors: Li, Lily (Author) , Weinhold, Niels (Author) , Försti, Asta (Author) , Goldschmidt, Hartmut (Author) , Hemminki, Kari (Author)
Format: Article (Journal)
Language:English
Published: September 12, 2017
In: Cell reports
Year: 2017, Volume: 20, Issue: 11, Pages: 2556-2564
ISSN:2211-1247
DOI:10.1016/j.celrep.2017.08.062
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1016/j.celrep.2017.08.062
Verlag, kostenfrei, Volltext: http://www.sciencedirect.com/science/article/pii/S2211124717311877
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Author Notes:Ni Li, David C. Johnson, Niels Weinhold, Scott Kimber, Sara E. Dobbins, Jonathan S. Mitchell, Ben Kinnersley, Amit Sud, Philip J. Law, Giulia Orlando, Matthew Scales, Christopher P. Wardell, Asta Försti, Phuc H. Hoang, Molly Went, Amy Holroyd, Fadi Hariri, Tomi Pastinen, Tobias Meissner, Hartmut Goldschmidt, Kari Hemminki, Gareth J. Morgan, Martin Kaiser, and Richard S. Houlston
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Summary:Summary - Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by which it influences tumorigenesis. We show that rs6877329 G > C resides in a predicted enhancer element that physically interacts with the transcription start site of ELL2. The rs6877329-C risk allele is associated with reduced enhancer activity and lowered ELL2 expression. Since ELL2 is critical to the B cell differentiation process, reduced ELL2 expression is consistent with inherited genetic variation contributing to arrest of plasma cell development, facilitating MM clonal expansion. These data provide evidence for a biological mechanism underlying a hereditary risk of MM at 5q15.
Item Description:Gesehen am 14.09.2018
Physical Description:Online Resource
ISSN:2211-1247
DOI:10.1016/j.celrep.2017.08.062

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