Pain management in photodynamic therapy using a nitrous oxide/oxygen mixture: a prospective, within-patient, controlled clinical trial
Background Photodynamic therapy is an effective treatment for actinic keratoses. Nevertheless, severe pain during the procedure is a serious adverse effect, which leads to interruption or even termination. Complete pain relief remains a difficult challenge. Objective To evaluate the effect of a nitr...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2017
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| In: |
Journal of the European Academy of Dermatology and Venereology
Year: 2017, Volume: 31, Issue: 1, Pages: 70-74 |
| ISSN: | 1468-3083 |
| DOI: | 10.1111/jdv.13788 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1111/jdv.13788 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jdv.13788 
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| Author Notes: | C. Fink, L. Uhlmann, A. Enk, P. Gholam |
| Summary: | Background Photodynamic therapy is an effective treatment for actinic keratoses. Nevertheless, severe pain during the procedure is a serious adverse effect, which leads to interruption or even termination. Complete pain relief remains a difficult challenge. Objective To evaluate the effect of a nitrous oxide/oxygen mixture on pain intensity during photodynamic therapy. Methods This clinical trial has been designed as a prospective, single-centre, explorative, controlled, observational study. Results We were able to detect a significant overall pain reduction of 55.2% after application of a nitrous oxide/oxygen mixture by means of an intra-individual comparison. Furthermore, the total number of therapy interruption significantly decreased by 82% after the inhalation analgesia. Additionally, treatment satisfaction ranged from ‘extremely to very satisfied’. Conclusions This study shows that analgesia by means of a nitrous oxide/oxygen mixture is a very effective and well-tolerated method for achieving significant pain reduction during photodynamic therapy. |
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| Item Description: | First published: 09 July 2016 Gesehen am 22.08.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1468-3083 |
| DOI: | 10.1111/jdv.13788 |