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Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex

The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a...

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Bibliographic Details
Main Authors: Melzer, Sarah (Author) , Michael, Magdalena (Author) , Caputi, Antonio (Author) , Eliava, Marina (Author) , Fuchs, Elke C. (Author) , Monyer, Hannah (Author)
Format: Article (Journal)
Language:English
Published: 2012
In: Science
Year: 2012, Volume: 335, Issue: 6075, Pages: 1506-1510
ISSN:1095-9203
DOI:10.1126/science.1217139
Online Access:Verlag, Volltext: http://dx.doi.org/10.1126/science.1217139
Verlag, Volltext: https://f1000.com/prime/715597805
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Author Notes:Sarah Melzer, Magdalena Michael, Antonio Caputi, Marina Eliava, Elke C. Fuchs, Miles A. Whittington, Hannah Monyer
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Summary:The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.
Item Description:Gesehen am 17.09.2018
Physical Description:Online Resource
ISSN:1095-9203
DOI:10.1126/science.1217139

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