Diagnostic performance of the MelaFind device in a real-life clinical setting
Background MelaFind is a multispectral computer vision system intended to provide additional information on melanocytic lesions suspected of being melanoma by objectively assessing their three-dimensional morphology. Objectives Analysis of the diagnostic performance of MelaFind in a real-life clin...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 March 2017
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| In: |
Journal der Deutschen Dermatologischen Gesellschaft
Year: 2017, Volume: 15, Issue: 4, Pages: 414-419 |
| ISSN: | 1610-0387 |
| DOI: | 10.1111/ddg.13220 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1111/ddg.13220 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13220 
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| Author Notes: | Christine Fink, Claudia Jaeger, Katharina Jaeger, Holger A. Haenssle |
| Summary: | Background MelaFind is a multispectral computer vision system intended to provide additional information on melanocytic lesions suspected of being melanoma by objectively assessing their three-dimensional morphology. Objectives Analysis of the diagnostic performance of MelaFind in a real-life clinical setting. Patients and methods In this observational study, 360 pigmented skin lesions (PSL) in 111 patients were assessed by office-based dermatologists using MelaFind. Scores ≥ 2 were considered to be suspicious of malignancy. The decision for surgical excision was left to the discretion of the examining dermatologists. Results MelaFind scores ≥ 2 were observed in 147 of 360 PSL (40.8 %). Of the 107 excised lesions with a MelaFind-score ≥ 2, the diagnosis of melanoma was made in three cases; 53 (49.5 %) lesions proved to be dysplastic nevi. Among all lesions biopsied (n = 113), the sensitivity and specificity of MelaFind was 100 % and 5.5 %, respectively. While a higher specificity of 68.5 % may be assumed with respect to the overall data set (n = 360), this assumption is limited by incomplete follow-up data required to confirm that all non-excised lesions with a score < 2 were actually benign. Conclusion The high sensitivity of MelaFind facilitated the detection of melanoma. The overall specificity and benign-to-malignant ratio of excised lesions were acceptable. These parameters may be improved by using higher cutoff scores for excisional biopsies, and by more vigorously selecting PSL for MelaFind examination. |
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| Item Description: | Gesehen am 22.08.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1610-0387 |
| DOI: | 10.1111/ddg.13220 |