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Activation of pro-survival metabolic networks by 1,25(OH)2D3 does not hamper the sensitivity of breast cancer cells to chemotherapeutics

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We have previously identified 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the bioactive form of vitamin D3, as a potent regulator of energy-utilization and nutrient-sensing pathways in prostate cancer cells. In the current study, we investigated the effects of 1,25(OH)2D3 on breast cancer (BCa) cell met...

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Main Authors: Abu El Maaty, Mohamed A. (Author) , Dabiri, Yasamin (Author) , Almouhanna, Fadi (Author) , Blagojević, Biljana (Author) , Theobald, Jannick (Author) , Büttner, Michael (Author) , Wölfl, Stefan (Author)
Format: Article (Journal)
Language:English
Published: 30 August 2018
In: Cancer & metabolism
Year: 2018, Volume: 6
ISSN:2049-3002
DOI:10.1186/s40170-018-0183-6
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s40170-018-0183-6
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s40170-018-0183-6
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Author Notes:Mohamed A. Abu el Maaty, Yasamin Dabiri, Fadi Almouhanna, Biljana Blagojevic, Jannick Theobald, Michael Büttner and Stefan Wölfl
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Summary:We have previously identified 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the bioactive form of vitamin D3, as a potent regulator of energy-utilization and nutrient-sensing pathways in prostate cancer cells. In the current study, we investigated the effects of 1,25(OH)2D3 on breast cancer (BCa) cell metabolism using cell lines representing distinct molecular subtypes, luminal (MCF-7 and T-47D), and triple-negative BCa (MDA-MB-231, MDA-MB-468, and HCC-1143).
Item Description:Published 30 August 2018
Gesehen am 20.09.2018
Im Titel sind die Ziffern "2" und "3" tiefgestellt
Physical Description:Online Resource
ISSN:2049-3002
DOI:10.1186/s40170-018-0183-6

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