Screening for potential prophylactics targeting sporozoite motility through the skin
Anti-malarial compounds have not yet been identified that target the first obligatory step of infection in humans: the migration of Plasmodium sporozoites in the host dermis. This movement is essential to find and invade a blood vessel in order to be passively transported to the liver. Here, an imag...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
31 August 2018
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| In: |
Malaria journal
Year: 2018, Volume: 17 |
| ISSN: | 1475-2875 |
| DOI: | 10.1186/s12936-018-2469-0 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s12936-018-2469-0 Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12936-018-2469-0 
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| Author Notes: | Ross G. Douglas, Miriam Reinig, Matthew Neale and Friedrich Frischknecht |
| Summary: | Anti-malarial compounds have not yet been identified that target the first obligatory step of infection in humans: the migration of Plasmodium sporozoites in the host dermis. This movement is essential to find and invade a blood vessel in order to be passively transported to the liver. Here, an imaging screening pipeline was established to screen for compounds capable of inhibiting extracellular sporozoites. |
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| Item Description: | Gesehen am 25.09.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1475-2875 |
| DOI: | 10.1186/s12936-018-2469-0 |