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Sulforaphane enhances irradiation effects in terms of perturbed cell cycle progression and increased DNA damage in pancreatic cancer cells

Sulforaphane (SFN), an herbal isothiocyanate enriched in cruciferous vegetables like broccoli and cauliflower, has gained popularity for its antitumor effects in cell lines such as pancreatic cancer. Antiproliferative as well as radiosensitizing properties were reported for head and neck cancer but...

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Bibliographic Details
Main Authors: Naumann, Patrick (Author) , Liermann, Jakob (Author) , Fortunato, Franco (Author) , Weber, Klaus-Josef (Author) , Debus, Jürgen (Author)
Format: Article (Journal)
Language:English
Published: July 10, 2017
In: PLOS ONE
Year: 2017, Volume: 12, Issue: 7
ISSN:1932-6203
DOI:10.1371/journal.pone.0180940
Online Access:Resolving-System, kostenfrei, Volltext: http://dx.doi.org/10.1371/journal.pone.0180940
Verlag, kostenfrei, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0180940
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Author Notes:Patrick Naumann, Jakob Liermann, Franco Fortunato, Thomas E. Schmid, Klaus-Josef Weber, Jürgen Debus, Stephanie E. Combs
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Summary:Sulforaphane (SFN), an herbal isothiocyanate enriched in cruciferous vegetables like broccoli and cauliflower, has gained popularity for its antitumor effects in cell lines such as pancreatic cancer. Antiproliferative as well as radiosensitizing properties were reported for head and neck cancer but little is known about its effects in pancreatic cancer cells in combination with irradiation (RT). In four established pancreatic cancer cell lines we investigated clonogenic survival, analyzed cell cycle distribution and compared DNA damage via flow cytometry and western blot after treatment with SFN and RT.
Item Description:Gesehen am 26.09.2018
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0180940

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