Establishing a porcine model of small for size syndrome following liver resection
Background. Small for size syndrome (SFSS) is responsible for a high proportion of mortalities and morbidities following extended liver resection. Aim. The aim of this study was to establish a porcine model of SFSS. Methods. Twenty-four Landrace pigs underwent liver resection with a remnant liver vo...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
29 August 2017
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| In: |
Canadian journal of gastroenterology & hepatology
Year: 2017, Pages: 1-8 |
| ISSN: | 2291-2797 |
| DOI: | 10.1155/2017/5127178 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1155/2017/5127178 Verlag, kostenfrei, Volltext: https://www.hindawi.com/journals/cjgh/2017/5127178/ 
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| Author Notes: | Mohammad Golriz, Maryam Ashrafi, Elias Khajeh, Ali Majlesara, Christa Flechtenmacher, and Arianeb Mehrabi |
| Summary: | Background. Small for size syndrome (SFSS) is responsible for a high proportion of mortalities and morbidities following extended liver resection. Aim. The aim of this study was to establish a porcine model of SFSS. Methods. Twenty-four Landrace pigs underwent liver resection with a remnant liver volume of 50% (group A, ), 25% (group B, ), and 15% (group C, ). After resection, the animals were followed up for 8 days and clinical, laboratory, and histopathological outcomes were evaluated. Results. The survival rate was significantly lower in group C compared with the other groups (). The international normalized ratio, bilirubin, aspartate transaminase, alanine transaminase, and alkaline phosphatase levels increased shortly after surgery in groups B and C, but no change was observed in group A ( for all analyses). The histopathological findings in group A were mainly mild mitoses, in group B severe mitoses and hepatocyte ballooning, moderate congestion, and hemorrhage, along with mild necrosis, and in group C extended tissue damage with severe necrosis, hemorrhage, and congestion. Conclusions. Combination of clinical, laboratory, and histopathological evaluations is needed to confirm the diagnosis of SFSS. 75% liver resection in porcine model results in SFSS. 85% liver resection causes irreversible liver failure. |
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| Item Description: | Gesehen am 27.09.2018 |
| Physical Description: | Online Resource |
| ISSN: | 2291-2797 |
| DOI: | 10.1155/2017/5127178 |