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Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours

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Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine the resemblance of hepatocellular carcinoma (HCC) cell lines to human liver tumours, specifically in the expre...

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Main Authors: Nwosu, Zeribe C. (Author) , Rothley, Melanie (Author) , Piorońska, Weronika (Author) , Ebert, Matthias (Author) , Sleeman, Jonathan P. (Author) , Wölfl, Stefan (Author) , Meyer, Christoph (Author) , Dooley, Steven (Author)
Format: Article (Journal)
Language:English
Published: 3 September 2018
In: Journal of experimental & clinical cancer research
Year: 2018, Volume: 37
ISSN:1756-9966
DOI:10.1186/s13046-018-0872-6
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13046-018-0872-6
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13046-018-0872-6
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Author Notes:Zeribe C. Nwosu, Nadia Battello, Melanie Rothley, Weronika Piorońska, Barbara Sitek, Matthias P. Ebert, Ute Hofmann, Jonathan Sleeman, Stefan Wölfl, Christoph Meyer, Dominik A. Megger and Steven Dooley
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Summary:Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine the resemblance of hepatocellular carcinoma (HCC) cell lines to human liver tumours, specifically in the expression of deregulated metabolic targets in clinical tissue samples.
Item Description:Gesehen am 27.09.2018
Physical Description:Online Resource
ISSN:1756-9966
DOI:10.1186/s13046-018-0872-6

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