Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours
Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine the resemblance of hepatocellular carcinoma (HCC) cell lines to human liver tumours, specifically in the expre...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 September 2018
|
| In: |
Journal of experimental & clinical cancer research
Year: 2018, Jahrgang: 37 |
| ISSN: | 1756-9966 |
| DOI: | 10.1186/s13046-018-0872-6 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13046-018-0872-6 Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13046-018-0872-6 
|
| Verfasserangaben: | Zeribe C. Nwosu, Nadia Battello, Melanie Rothley, Weronika Piorońska, Barbara Sitek, Matthias P. Ebert, Ute Hofmann, Jonathan Sleeman, Stefan Wölfl, Christoph Meyer, Dominik A. Megger and Steven Dooley |
| Zusammenfassung: | Although metabolism is profoundly altered in human liver cancer, the extent to which experimental models, e.g. cell lines, mimic those alterations is unresolved. Here, we aimed to determine the resemblance of hepatocellular carcinoma (HCC) cell lines to human liver tumours, specifically in the expression of deregulated metabolic targets in clinical tissue samples. |
|---|---|
| Beschreibung: | Gesehen am 27.09.2018 |
| Beschreibung: | Online Resource |
| ISSN: | 1756-9966 |
| DOI: | 10.1186/s13046-018-0872-6 |