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Expression of HMB45, MelanA and SOX10 is rare in non-small cell lung cancer

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Non-small cell lung cancer (NSCLC) and melanoma are frequent entities in routine diagnostics. Whereas the differential diagnosis is usually straight forward based on histomorphology, it can be challenging in poorly differentiated tumors as melanoma may mimic various histological patterns. Distinctio...

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Main Authors: Kriegsmann, Mark (Author) , Kriegsmann, Katharina (Author) , Harms, Alexander (Author) , Longuespée, Rémi (Author) , Zgorzelski, Christiane (Author) , Leichsenring, Jonas (Author) , Muley, Thomas (Author) , Winter, Hauke (Author) , Kazdal, Daniel (Author) , Goeppert, Benjamin (Author) , Warth, Arne (Author)
Format: Article (Journal)
Language:English
Published: 11 September 2018
In: Diagnostic pathology
Year: 2018, Volume: 13
ISSN:1746-1596
DOI:10.1186/s13000-018-0751-7
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/s13000-018-0751-7
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13000-018-0751-7
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Author Notes:Mark Kriegsmann, Katharina Kriegsmann, Alexander Harms, Rémi Longuespée, Christiane Zgorzelski, Jonas Leichsenring, Thomas Muley, Hauke Winter, Daniel Kazdal, Benjamin Goeppert and Arne Warth
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Summary:Non-small cell lung cancer (NSCLC) and melanoma are frequent entities in routine diagnostics. Whereas the differential diagnosis is usually straight forward based on histomorphology, it can be challenging in poorly differentiated tumors as melanoma may mimic various histological patterns. Distinction of the two entities is of outmost importance as both are treated differently. HMB45 and MelanA are recommended immunohistological markers for melanoma in this scenario. SOX10 has been described as an additional marker for melanoma. However, comprehensive large-scale data about the expression of melanoma markers in NSCLC tumor tissue specimen are lacking so far.
Item Description:Gesehen am 27.09.2018
Physical Description:Online Resource
ISSN:1746-1596
DOI:10.1186/s13000-018-0751-7

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