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Thromboembolic stroke in C57BL/6 mice monitored by 9.4 T MRI using a 1H cryo probe

A new thromboembolic animal model showed beneficial effects of t-PA with an infarct volume reduction of 36.8% in swiss mice. Because knock-out animal experiments for stroke frequently used C57BL76 mice we evaluated t-PA effects in this mouse strain and measured infarct volume and vascular recanalisa...

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Bibliographic Details
Main Authors: Langhauser, Friederike (Author) , Grudzenski-Theis, Saskia (Author) , Lemke, Andreas (Author) , Alonso, Angelika (Author) , Schad, Lothar R. (Author) , Hennerici, Michael G. (Author) , Meairs, Stephen (Author) , Fatar, Marc (Author)
Format: Article (Journal)
Language:English
Published: 12 September 2012
In: Experimental & translational stroke medicine
Year: 2012, Volume: 4
ISSN:2040-7378
DOI:10.1186/2040-7378-4-18
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/2040-7378-4-18
Verlag, kostenfrei, Volltext: https://doi.org/10.1186/2040-7378-4-18
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Author Notes:Friederike L. Langhauser, Patrick M. Heiler, Saskia Grudzenski, Andreas Lemke, Angelika Alonso, Lothar R. Schad, Michael G. Hennerici, Stephen Meairs and Marc Fatar
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Summary:A new thromboembolic animal model showed beneficial effects of t-PA with an infarct volume reduction of 36.8% in swiss mice. Because knock-out animal experiments for stroke frequently used C57BL76 mice we evaluated t-PA effects in this mouse strain and measured infarct volume and vascular recanalisation in-vivo by using high-field 9.4 T MRI and a 1H surface cryo coil.
Item Description:Gesehen am 01.10.2018
Physical Description:Online Resource
ISSN:2040-7378
DOI:10.1186/2040-7378-4-18

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