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Revisiting the prognostic value of monocyte chemotactic protein 1 and interleukin-6 in the sepsis-3 era

Background: Monocyte Chemotactic Protein 1 (MCP1) and latest sepsis-3 criteria are poorly represented within studies evaluating biomarkers in sepsis. Therefore, this study evaluates the prognostic value of MCP-1 compared to interleukin-6 (IL-6) in patients with sepsis and septic shock according to s...

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Main Authors: Barre, Max (Author) , Behnes, Michael (Author) , Hamed, Sonja (Author) , Pauly, Dominic (Author) , Lepiorz, Dominic (Author) , Lang, Siegfried (Author) , Akın, Ibrahim (Author) , Borggrefe, Martin (Author) , Hoffmann, Ursula (Author)
Format: Article (Journal)
Language:English
Published: 2018
In: Journal of critical care
Year: 2017, Volume: 43, Pages: 21-28
ISSN:1557-8615
DOI:10.1016/j.jcrc.2017.08.024
Online Access:Verlag, Volltext: http://dx.doi.org/10.1016/j.jcrc.2017.08.024
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S088394411730847X
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Author Notes:Max Barre, Michael Behnes, Sonja Hamed, Dominic Pauly, Dominic Lepiorz, Siegfried Lang, Ibrahim Akin, Martin Borggrefe, Thomas Bertsch, Ursula Hoffmann
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Summary:Background: Monocyte Chemotactic Protein 1 (MCP1) and latest sepsis-3 criteria are poorly represented within studies evaluating biomarkers in sepsis. Therefore, this study evaluates the prognostic value of MCP-1 compared to interleukin-6 (IL-6) in patients with sepsis and septic shock according to sepsis-3 criteria. Methods: 136 patients with sepsis or septic shock were included within 24h of intensive care unit (ICU) admission. MCP-1, IL-6, procalcitonin (PCT), C-reactive protein (CRP) and white blood cells (WBC) were measured on days 1, 3 and 8. All-cause mortality was followed up at 30days and 6months. Results: Both MCP-1 and IL-6 levels revealed valuable prognostic discrimination of 30-day and 6-months all-cause mortality on day 1 and 3 (MCP-1: range of AUCs 0.62-0.65, p<0.039; IL-6: range of AUCs 0.65-0.70, p<0.021) compared to PCT, CRP, SOFA and APACHE II score. MCP-1 levels within the 4th quartile revealed the highest mortality at 30days and 6months compared to patients with lower levels (range of hazard ratio (HR)=2.1-3.3, p<0.041). The prognostic value of MCP-1 sustained in multivariate regression models and was comparable to that of IL-6. Conclusion: Both MCP-1 and IL-6 revealed prognostic value for short- and mid-term all-cause mortality in patients with sepsis and septic shock according to latest sepsis-3 definitions.
Item Description:Available online 15 August 2017
Gesehen am 02.10.2018
Physical Description:Online Resource
ISSN:1557-8615
DOI:10.1016/j.jcrc.2017.08.024

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