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Prospective evaluation of neuromediator dynamics in castration-resistant prostate cancer patients during docetaxel

Aim: Aim of the study was to detect small cell/neuroendocrine (SCNC) transformation in metastatic castration-resistant prostate cancer (mCRPC) that is a challenging procedure. We investigated the role of neuromediator dynamics as potential evidence of SCNC in patients undergoing docetaxel therapy. P...

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Bibliographic Details
Main Authors: Hardenberg, Jost von (Author) , Schwartz, Maike (Author) , Weiß, Christel (Author)
Format: Article (Journal)
Language:English
Published: September 2017
In: Anticancer research
Year: 2017, Volume: 37, Issue: 9, Pages: 5117-5124
ISSN:1791-7530
DOI:10.21873/anticanres.11931
Online Access:Verlag, Volltext: http://dx.doi.org/10.21873/anticanres.11931
Verlag, Volltext: http://ar.iiarjournals.org/content/37/9/5117.abstract
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Author Notes:Jost von Hardenberg, Maike Schwartz, Thorsten Werner, Stefan Fuxius, Markus Müller, Thomas Frangenheim, Christian Bolenz, Christel Weiss and Elmar Heinrich
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Summary:Aim: Aim of the study was to detect small cell/neuroendocrine (SCNC) transformation in metastatic castration-resistant prostate cancer (mCRPC) that is a challenging procedure. We investigated the role of neuromediator dynamics as potential evidence of SCNC in patients undergoing docetaxel therapy. Patients and Methods: A multi-institutional, prospective observational study was conducted. Patients undergoing docetaxel treatment were included. Chromogranin A (CGA), neuron-specific enolase (NSE), and pro-gastrin releasing peptide (Pro-GRP) were sequentially evaluated at predefined time points. Outcome measures were overall survival (OS), progression-free survival (PFS) and PSA nadir. Results: Fifty-two patients were included. A general rise in CGA levels was observed. Patients with a high CGA rise (100%ULN: CGA ≥98.1ng/ml) between the 1st and 3rd cycle trended towards a decreased OS (p=0.0649) and showed a decreased PFS (p=0.0369). In multivariate analysis, continuous CGA rise correlated with PFS (p=0.0553; HR 1.136), but was not an independent predictor of OS. Conclusion: Patients with an early high CGA rise may demonstrate a subgroup with poor outcome due to underlying SCNC transformation. Monitoring of CGA appears to be an option worth considering.
Item Description:Gesehen am 08.10.2018
Physical Description:Online Resource
ISSN:1791-7530
DOI:10.21873/anticanres.11931

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