BMP and TGFbeta pathways in human central chondrosarcoma: enhanced endoglin and Smad 1 signaling in high grade tumors
As major regulators of normal chondrogenesis, the bone morphogenic protein (BMP) and transforming growth factor β (TGFB) signaling pathways may be involved in the development and progression of central chondrosarcoma. In order to uncover their possible implication, the aim of this study was to perfo...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 October 2012
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| In: |
BMC cancer
Year: 2012, Volume: 12 |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/1471-2407-12-488 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1186/1471-2407-12-488 Verlag, kostenfrei, Volltext: https://doi.org/10.1186/1471-2407-12-488 
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| Author Notes: | Stephane Boeuf, Judith VMG Bovée, Burkhard Lehner, Brendy van den Akker, Maayke van Ruler, Anne-Marie Cleton-Jansen, and Wiltrud Richter |
| Summary: | As major regulators of normal chondrogenesis, the bone morphogenic protein (BMP) and transforming growth factor β (TGFB) signaling pathways may be involved in the development and progression of central chondrosarcoma. In order to uncover their possible implication, the aim of this study was to perform a systematic quantitative study of the expression of BMPs, TGFBs and their receptors and to assess activity of the corresponding pathways in central chondrosarcoma. |
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| Item Description: | Gesehen am 10.10.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1471-2407 |
| DOI: | 10.1186/1471-2407-12-488 |