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RAS-pathway mutation patterns define epigenetic subclasses in juvenile myelomonocytic leukemia

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Juvenile myelomonocytic leukemia (JMML) is an aggressive disease with limited options for treatment. Here, the authors analyse the DNA methylome and mutational profile of JMML to define three subgroups with unique molecular and clinical characteristics.

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Main Authors: Lipka, Daniel (Author) , Witte, Tania (Author) , Toth, Reka (Author) , Yang, Jing (Author) , Wiesenfarth, Manuel (Author) , Nöllke, Peter (Author) , Fischer, Alexandra (Author) , Brocks, David (Author) , Gu, Zuguang (Author) , Park, Jeongbin (Author) , Strahm, Brigitte (Author) , Wlodarski, Marcin (Author) , Yoshimi-Nöllke, Ayami (Author) , Claus, Rainer (Author) , Lübbert, Michael (Author) , Busch, Hauke (Author) , Börries, Melanie (Author) , Hartmann, Mark (Author) , Schönung, Maximilian (Author) , Kilik, Umut (Author) , Langstein, Jens (Author) , Wierzbinska, Justyna A. (Author) , Pabst, Caroline (Author) , Garg, Swati (Author) , Catalá, Albert (Author) , Moerloose, Barbara de (Author) , Dworzak, Michael (Author) , Hasle, Henrik (Author) , Locatelli, Franco (Author) , Masetti, Riccardo (Author) , Schmugge Liner, Markus (Author) , Smith, Owen (Author) , Stary, Jan (Author) , Ussowicz, Marek (Author) , Heuvel-Eibrink, Marry M. van den (Author) , Assenov, Yassen (Author) , Schlesner, Matthias (Author) , Niemeyer, Charlotte (Author) , Flotho, Christian (Author) , Plass, Christoph (Author)
Format: Article (Journal)
Language:English
Published: 19 December 2017
In: Nature Communications
Year: 2017, Volume: 8, Pages: 1-14
ISSN:2041-1723
DOI:10.1038/s41467-017-02177-w
Online Access:Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1038/s41467-017-02177-w
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41467-017-02177-w
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Author Notes:Daniel B. Lipka, Tania Witte, Reka Toth, Jing Yang, Manuel Wiesenfarth, Peter Nöllke, Alexandra Fischer, David Brocks, Zuguang Gu, Jeongbin Park, Brigitte Strahm, Marcin Wlodarski, Ayami Yoshimi, Rainer Claus, Michael Lübbert, Hauke Busch, Melanie Boerries, Mark Hartmann, Maximilian Schönung, Umut Kilik, Jens Langstein, Justyna A. Wierzbinska, Caroline Pabst, Swati Garg, Albert Catalá, Barbara De Moerloose, Michael Dworzak, Henrik Hasle, Franco Locatelli, Riccardo Masetti, Markus Schmugge, Owen Smith, Jan Stary, Marek Ussowicz, Marry M. van den Heuvel-Eibrink, Yassen Assenov, Matthias Schlesner, Charlotte Niemeyer, Christian Flotho & Christoph Plass
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Summary:Juvenile myelomonocytic leukemia (JMML) is an aggressive disease with limited options for treatment. Here, the authors analyse the DNA methylome and mutational profile of JMML to define three subgroups with unique molecular and clinical characteristics.
Item Description:Gesehen am 10.10.2018
Physical Description:Online Resource
ISSN:2041-1723
DOI:10.1038/s41467-017-02177-w

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