Physical activity prevents progression for cognitive impairment and vascular dementia: results from the LADIS (leukoaraiosis and disability) study
Background and Purpose: We aimed to study if physical activity could interfere with progression for cognitive impairment and dementia in older people with white matter changes living independently. Methods: The LADIS (Leukoaraiosis and Disability) prospective multinational European study evaluates t...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 1, 2012
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| In: |
Stroke
Year: 2012, Volume: 43, Issue: 12, Pages: 3331-3335 |
| ISSN: | 1524-4628 |
| DOI: | 10.1161/STROKEAHA.112.661793 |
| Online Access: | Verlag, kostenfrei, Volltext: http://dx.doi.org/10.1161/STROKEAHA.112.661793 Verlag, kostenfrei, Volltext: https://www.ahajournals.org/doi/10.1161/STROKEAHA.112.661793 
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| Author Notes: | Ana Verdelho, MD, Sofia Madureira, PsyD, José M. Ferro, MD, PhD, Hansjörg Baezner, MD, PhD, Christian Blahak, MD, Anna Poggesi, MD, Michael Hennerici, MD, Leonardo Pantoni, MD, PhD, Franz Fazekas, MD, Philip Scheltens, MD, PhD, Gunhild Waldemar, MD, DMSc, Anders Wallin, MD, PhD, Timo Erkinjuntti, MD, PhD, Domenico Inzitari, MD, on behalf of the LADIS study |
| Summary: | Background and Purpose: We aimed to study if physical activity could interfere with progression for cognitive impairment and dementia in older people with white matter changes living independently. Methods: The LADIS (Leukoaraiosis and Disability) prospective multinational European study evaluates the impact of white matter changes on the transition of independent elderly subjects into disability. Subjects were evaluated yearly during 3 years with a comprehensive clinical protocol and cognitive assessment with classification of cognitive impairment and dementia according to usual clinical criteria. Physical activity was recorded during the clinical interview. MRI was performed at entry and at the end of the study. Results: Six hundred thirty-nine subjects were included (74.1±5 years old, 55% women, 9.6±3.8 years of schooling, 64% physically active). At the end of follow-up, 90 patients had dementia (vascular dementia, 54; Alzheimer disease with vascular component, 34; frontotemporal dementia, 2), and 147 had... |
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| Item Description: | Gesehen am 12.10.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1524-4628 |
| DOI: | 10.1161/STROKEAHA.112.661793 |