Alloantigen-stimulated induction and release of CD30 in patients with end-stage renal failure
High serum levels of soluble CD30 (sCD30) are associated with poor renal allograft survival, and regulatory T cells (Tregs) influence allograft survival depending on CD30 signaling. However, how sCD30 modulates alloimmune responses remains poorly understood. We measured the level of Tregs and sCD30...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 August 2012
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| In: |
Human immunology
Year: 2012, Volume: 73, Issue: 11, Pages: 1102-1108 |
| ISSN: | 1879-1166 |
| DOI: | 10.1016/j.humimm.2012.08.015 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1016/j.humimm.2012.08.015 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0198885912005411 
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| Author Notes: | Sonia Y. Velásquez, Caner Süsal, Gerhard Opelz, Luis F. García, Cristiam M. Alvarez |
| Summary: | High serum levels of soluble CD30 (sCD30) are associated with poor renal allograft survival, and regulatory T cells (Tregs) influence allograft survival depending on CD30 signaling. However, how sCD30 modulates alloimmune responses remains poorly understood. We measured the level of Tregs and sCD30 in patients with end-stage renal failure (ESRF) and analyzed whether allo- or polyclonal stimulation of the patients’ T cells results in the expression and release of CD30. ESRF patients showed increased serum sCD30 levels and lower percentages of circulating Tregs as compared to healthy controls (HC) (p<0.001 and 0.024). Polyclonal and allogeneic stimulation resulted in higher expression of CD30, and after polyclonal stimulation, ESRF patients showed higher percentages of CD30-expressing T cells than HC (p<0.001). Compared to autologous stimulation, allogeneic stimulation induced significantly higher expression of CD30 on T cells of ESRF patients only. After polyclonal as well as allogeneic stimulation, an increased sCD30 content was found in culture supernatants of both ESRF patients and HC (p<0.001). Together with decreased Tregs, high serum sCD30 and increased induction of CD30 on T cells after polyclonal stimulation may explain exacerbated alloimmune responses and poor allograft survival in ESRF patients in whom immunosuppression is not able to control the alloimmune response. |
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| Item Description: | Gesehen am 17.10.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1879-1166 |
| DOI: | 10.1016/j.humimm.2012.08.015 |