The incomplete glutathione puzzle: just guessing at numbers and figures?
Significance: Glutathione metabolism is comparable to a jigsaw puzzle with too many pieces. It is supposed to comprise (i) the reduction of disulfides, hydroperoxides, sulfenic acids, and nitrosothiols, (ii) the detoxification of aldehydes, xenobiotics, and heavy metals, and (iii) the synthesis of eico...
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| Main Author: | |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
20 Nov 2017
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| In: |
Antioxidants & redox signaling
Year: 2017, Volume: 27, Issue: 15, Pages: 1130-1161 |
| ISSN: | 1557-7716 |
| DOI: | 10.1089/ars.2017.7123 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1089/ars.2017.7123 Verlag, Volltext: http://www.liebertpub.com/doi/10.1089/ars.2017.7123 
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| Author Notes: | Marcel Deponte |
| Summary: | Significance: Glutathione metabolism is comparable to a jigsaw puzzle with too many pieces. It is supposed to comprise (i) the reduction of disulfides, hydroperoxides, sulfenic acids, and nitrosothiols, (ii) the detoxification of aldehydes, xenobiotics, and heavy metals, and (iii) the synthesis of eicosanoids, steroids, and iron-sulfur clusters. In addition, glutathione affects oxidative protein folding and redox signaling. Here, I try to provide an overview on the relevance of glutathione-dependent pathways with an emphasis on quantitative data. |
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| Item Description: | Online ahead of editing: May 25, 2017 Gesehen am 17.10.2018 |
| Physical Description: | Online Resource |
| ISSN: | 1557-7716 |
| DOI: | 10.1089/ars.2017.7123 |